Lead Anticancer Agents of Crinine Alkaloids: Cytotoxic, Caspase-3, and Anti-angiogenic Exploration

Several alkaloids with anticancer activities have been reported among the Crinum species. In this study, an in silico screening of crinine was carried out to identify potential Caspase-3 activators and anti-angiogenic compounds. Thirty-one (31) were assessed for drug-likeness using SwissADME online Web server. Nine (9) alkaloids, satisfying Lipinski’s rules selected screened cytotoxic properties against cancer normal cell lines Cell Line Cytotoxity Predictor (CLC-Pred). The possessing drug-like showing good selectivity towards evaluated activating by docking VEGFR2 proteins, respectively. binding energy compounds compared those standard drugs. Powelline, augustine, undulatine possess demonstrated lung (A549) oligodendroglioma (Hs683) lines. Among these three compounds, powelline had best as a stimulant agent. are lead agents human oligodendroglioma.